exonuclease
Sign in to savethumb|200px|3′ to 5′ Exonuclease associated with Pol I
Research
16,198 papers- Exonuclease-based aptasensors: Promising for food safety and diagnostic aims.Talanta · 2023
- Single 3'-exonuclease-based multifragment DNA assembly method (SENAX).Scientific reports · 2022
- Non-Exonuclease Domain POLE Mutations Associated with Immunotherapy Benefit.The oncologist · 2022
- Mre11 exonuclease activity promotes irreversible mitotic progression under replication stress.Life science alliance · 2022
- Exonuclease EXD2 in mitochondrial translation.Nature cell biology · 2018
via PubMed
Wikidata facts
- Subclass of
- hydrolase
Show 3 more facts
- Commons category
- Exonucleases
- opposite of
- endonuclease
- EC enzyme number
- 3.1.-.-
Sources (2)
via Wikidata · CC0
~6 min read
Encyclopedic overview
8 sectionsContents
- Significance to polymerase
- ''E. coli'' types
- dnaQ
- Discoveries in humans
- Discoveries in yeast
- Discoveries in Coronaviruses
- References
- External links
thumb|200px|3′ to 5′ Exonuclease associated with Pol I
Exonucleases are enzymes that work by cleaving nucleotides one at a time from the end (exo) of a polynucleotide chain. A hydrolyzing reaction that breaks phosphodiester bonds at either the 3′ or the 5′ end occurs. Its close relative is the endonuclease, which cleaves phosphodiester bonds in the middle (endo) of a polynucleotide chain. Eukaryotes and prokaryotes have three types of exonucleases involved in the normal turnover of mRNA: 5′ to 3′ exonuclease (Xrn1), which is a dependent decapping protein; 3′ to 5′ exonuclease, an independent protein; and poly(A)-specific 3′ to 5′ exonuclease.
Excerpted from Wikipedia’s “exonuclease” article, available under the CC BY-SA 4.0 licence.