فیبرینوژن

Also known as fibrinogen complex family, fibrinogen, GO:0005577, factor I

Fibrinogen (coagulation factor I) is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiog

Key facts

Protein.OMIM: 134830
Protein family.Symbol: Fibrinogen_C
Protein family.Name: Fibrinogen alpha/beta chain family
Protein family.image: PDB 1m1j EBI.jpg
Protein family.caption: crystal structure of native chicken fibrinogen with two different bound ligands
Protein family.Pfam: PF00147
Protein family.InterPro: IPR002181
Protein family.SCOP: 1fza
Protein family.Pfam_clan: CL0422
Protein family.PROSITE: PDOC00445
Protein.Name: Fibrinogen beta chain
Protein.HGNCid: 3662
Protein.Symbol: FGB
Protein.EntrezGene: 2244
Protein.RefSeq: NM_000508
Protein.UniProt: P02671
Protein.Chromosome: 4
Protein.Arm: q