fibrinogen complex
Sign in to saveFibrinogen (coagulation factor I) is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiog
Key facts
- Protein.OMIM
- 134830
- Protein family.Symbol
- Fibrinogen_C
- Protein family.Name
- Fibrinogen alpha/beta chain family
- Protein family.image
- PDB 1m1j EBI.jpg
- Protein family.caption
- crystal structure of native chicken fibrinogen with two different bound ligands
- Protein family.Pfam
- PF00147
- Protein family.InterPro
- IPR002181
- Protein family.SCOP
- 1fza
- Protein family.Pfam_clan
- CL0422
- Protein family.PROSITE
- PDOC00445
- Protein.Name
- Fibrinogen beta chain
- Protein.HGNCid
- 3662
- Protein.Symbol
- FGB
- Protein.EntrezGene
- 2244
- Protein.RefSeq
- NM_000508
- Protein.UniProt
- P02671
- Protein.Chromosome
- 4
- Protein.Arm
- q
via Wikipedia infobox
Article
18 sectionsContents
- Genes
- Structure
- Blood clot formation
- Fibrinogen disorders
- Congenital afibrinogenemia
- Congenital hypofibrinogenemia
- Fibrinogen storage disease
- Congenital dysfibrinogenemia
- Hereditary fibrinogen Aα-Chain amyloidosis
- Acquired dysfibrinogenemia
- Congenital hypodysfibrinogenemia
- Cryofibrinogenemia
- Acquired hypofibrinogenemia
- Laboratory tests
- Hyperfibrinogenemia
- History
- References
- External links
Fibrinogen (coagulation factor I) is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby promotes revascularization and wound healing.
Reduced and/or dysfunctional fibrinogens occur in various congenital and acquired human fibrinogen-related disorders. These disorders represent a group of rare conditions in which individuals may present with severe episodes of pathological bleeding and thrombosis; these conditions are treated by supplementing blood fibrinogen levels and inhibiting blood clotting, respectively. These disorders may also be the cause of certain liver and kidney diseases.