FXYD1
Sign in to saveAlso known as PLM, FXYD domain containing ion transport regulator 1
Phospholemman (PLM) is a protein that in humans is encoded by the FXYD1 gene.
Gene data
FXYD1- Name
- FXYD domain containing ion transport regulator 1
- Type
- protein-coding
- Aliases
- PLM
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
FXYD domain containing ion transport regulator 1
- Symbol
- FXYD1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:35,133,987-35,143,109
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein FXYD1 PDB 2J1I.png
Show 5 more facts
- HomoloGene ID
- 3691
- exact match
- identifiers.org/ncbigene/5348
- genomic end
- 35634013
- genomic start
- 35138824
- cytogenetic location
- 19q13.12
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Function
- References
- Further reading
Phospholemman (PLM) is a protein that in humans is encoded by the FXYD1 gene.
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.