FXYD5

Name

FXYD domain containing ion transport regulator 5

Type

protein-coding

Position

35,154,440–35,171,796 (+)

Aliases

DYSAD, HSPC113, IWU1, KCT1, OIT2, PRO6241, RIC

Ensembl

ENSG00000089327

RefSeq RNA

NM_001164605.2, NM_001320912.2, NM_001320913.2, NM_014164.6, NM_144779.3

RefSeq protein

NP_001158077.1, NP_001307841.1, NP_001307842.1, NP_054883.3, NP_659003.1

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., [email protected]., Sep 2009].

via MyGene.info

Gene · Ensembl

FXYD domain containing ion transport regulator 5

Symbol

FXYD5

Biotype

Protein coding

Organism

Homo sapiens

Location

19:35,154,440-35,171,796

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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