GLE1

Name

GLE1 RNA export mediator

Type

protein-coding

Position

128,504,655–128,543,874 (+)

Aliases

CAAHC, CAAHD, GLE1L, LCCS, LCCS1, hGLE1

Ensembl

ENSG00000119392

RefSeq RNA

NM_001003722.2, NM_001411013.1, NM_001499.2, XM_006717060.4, XM_011518549.2

RefSeq protein

NP_001003722.1, NP_001397942.1, NP_001490.1, XP_006717123.1, XP_011516851.1

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

via Wikidata · CC0