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GeneQ14909910· pop 11· linked from 509 articles

GLP1R

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Also known as glucagon-like peptide 1 receptor, GLP-1, GLP-1-R, GLP-1R, glucagon like peptide 1 receptor

receptor activated by peptide hormone GLP-1

Gene data

GLP1R

Name: glucagon like peptide 1 receptor
Type: protein-coding
Position: 39,048,562–39,091,303 (+)
Aliases: GLP-1, GLP-1-R, GLP-1R
Ensembl: ENSG00000112164
RefSeq RNA: NM_002062.5, NR_136562.2, NR_136563.2
RefSeq protein: NP_002053.3

This gene encodes a 7-transmembrane receptor for glucagon-like peptide 1 (GLP-1), which stimulates glucose-dependent insulin secretion. The receptor, located on the cell surface, is internalized upon ligand binding and triggers signaling pathways that regulate insulin release, appetite, gastric emptying, and energy balance. It also has neuroprotective and cardiovascular effects. Polymorphisms in this gene are linked to type 2 diabetes risk, and the receptor is a key drug target for diabetes, obesity, and stroke therapies. [provided by RefSeq, Mar 2026].

Gene Ontology

Biological process

cell surface receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration learning or memory

Molecular function

transmembrane signaling receptor activity transmembrane signaling receptor activity G protein-coupled receptor activity glucagon receptor activity glucagon receptor activity protein binding G protein-coupled peptide receptor activity glucagon-like peptide 1 receptor activity

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane plasma membrane plasma membrane membrane membrane

Pathways

cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Insulin secretion - Homo sapiens (human)Metabolism Metabolism Signal Transduction Integration of energy metabolism Integration of energy metabolism Signaling by GPCR Class B/2 (Secretin family receptors)

via MyGene.info

Gene · Ensembl

glucagon like peptide 1 receptor

Symbol: GLP1R
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:39,048,562-39,091,303
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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