Structure via PubChem · Public domain (PubChem)
Glutetimide
Sign in to saveAlso known as Doriden®, 2-Ethyl-2-phenylglutarimide, Doriden, Glutethimide
farmaco
Chemical data
- Formula
- C13H15NO2
- Molecular weight
- 217.26 g/mol
- IUPAC name
- 3-ethyl-3-phenylpiperidine-2,6-dione
- SMILES
- CCC1(CCC(=O)NC1=O)C2=CC=CC=C2
- InChIKey
- JMBQKKAJIKAWKF-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 46.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1976
- Admin. routes
- oral
via ChEMBL · EBI
Research
2,279 papers- Glutethimide (Doriden) poisoning. Controversies in treatment.Arizona medicine · 1971
- Glutethimide rebound.Lancet (London, England) · 1970
- [Glutethimide poisoning (alpha-phenylo-alpha-ethylo-glutaric acid imide)].Polski tygodnik lekarski (Warsaw, Poland : 1960) · 1966
- Glutethimide abuse.The American journal of psychiatry · 1982
- Chronic glutethimide abuse.The British journal of clinical practice · 1986
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 217.110279
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₃H₁₅NO₂
- World Health Organisation international non-proprietary name
- glutethimide
- medical condition treated
- insomnia
- canonical SMILES
- CCC1(CCC(=O)NC1=O)C2=CC=CC=C2
- defined daily dose
- 0.25
- Commons category
- Glutethimide
via Wikidata · CC0
Article · Italiano
La glutetimide è un sedativo ipnotico che venne introdotto in terapia medica nel 1954 come un'alternativa valida e sicura ai barbiturici per curare l'insonnia. Il farmaco per certi aspetti mantiene sul sistema nervoso centrale (SNC) un effetto deprimente simile a quello dei barbiturici. Dopo un breve periodo di utilizzo fu chiaro a tutti i clinici che la glutetimide era in grado di provocare dipendenza e sintomi di astinenza altrettanto gravi e simili a quelli dei barbiturici.
Abstract from DBpedia / Wikipedia · CC BY-SA