glycosaminoglycan
class=skin-invert-image|thumb|240px|right|The repeating disaccharide unit (GlcUA(1β→3)GalNAc(1β→4))n of chondroitin sulfate. For polysaccharide nomenclature see here. R1, R2, R3 may have different values. Glycosaminoglycans (GAGs) or mucopolysaccharides are long, linear polysaccharides consisting of repeating disaccharide units (i.e., two-sugar units). The repeating two-sugar unit consists of a uronic sugar and an amino sugar, except in the case of the sulfated glycosaminoglycan keratan, where, in place of the uronic sugar there is a galactose unit. GAGs are found in vertebrates, invertebrates
Research
146,852 papers- Glycosaminoglycan interaction networks and databases.Current opinion in structural biology · 2022
- Modeling glycosaminoglycan-protein complexes.Current opinion in structural biology · 2022
- Microbial glycosaminoglycan glycosyltransferases.Glycobiology · 2002
- Editorial: Proteoglycans and Glycosaminoglycan Modification in Immune Regulation and Inflammation.Frontiers in immunology · 2020
- The molecular mechanisms of glycosaminoglycan biosynthesis regulating chondrogenesis and endochondral ossification.Life sciences · 2023
via PubMed
Article
10 sectionsContents
- Production
- HSGAG and CSGAG
- Keratan sulfate types
- Hyaluronic acid class
- Pharmacodynamics
- Classification
- Abbreviations
- See also
- References
- External links
class=skin-invert-image|thumb|240px|right|The repeating disaccharide unit (GlcUA(1β→3)GalNAc(1β→4))n of chondroitin sulfate. For polysaccharide nomenclature see here. R1, R2, R3 may have different values. Glycosaminoglycans (GAGs) or mucopolysaccharides are long, linear polysaccharides consisting of repeating disaccharide units (i.e., two-sugar units). The repeating two-sugar unit consists of a uronic sugar and an amino sugar, except in the case of the sulfated glycosaminoglycan keratan, where, in place of the uronic sugar there is a galactose unit. GAGs are found in vertebrates, invertebrates and bacteria. Because GAGs are highly polar molecules and attract water; the body uses them as lubricants or shock absorbers.
Mucopolysaccharidoses are a group of metabolic disorders in which abnormal accumulations of glycosaminoglycans occur due to enzyme deficiencies.