sulodexide
Sign in to saveSulodexide, traded as Aterina, is a highly purified mixture of glycosaminoglycans composed of heparan sulfate (80%) and dermatan sulfate (20%).
Research
445 papers- Sulodexide in venous disease.Journal of thrombosis and haemostasis : JTH · 2019
- Sulodexide improves vascular permeability via glycocalyx remodelling in endothelial cells during sepsis.Frontiers in immunology · 2023
- Sulodexide for Diabetic-Induced Disabilities: A Systematic Review and Meta-Analysis.Advances in therapy · 2021
- Sulodexide for treating venous leg ulcers.The Cochrane database of systematic reviews · 2016
- Sulodexide for the Symptoms and Signs of Chronic Venous Disease: A Systematic Review and Meta-analysis.Advances in therapy · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 295.128054024
- Has use
- medication
Show 3 more facts
- has characteristic
- biopharmaceutical
- canonical SMILES
- CNc1ncnc2c1ncn2C1OC(CO)C(O)C1OC
- chemical formula
- C₁₂H₁₇N₅O₄
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Pharmacology
- Uses
- References
- External links
Sulodexide, traded as Aterina, is a highly purified mixture of glycosaminoglycans composed of heparan sulfate (80%) and dermatan sulfate (20%).
==Pharmacology== The low molecular weight of both sulodexide fractions allows for extensive oral absorption compared to unfractionated heparin. The pharmacological effects of sulodexide differ substantially from other glycosaminoglycans and are mainly characterized by a prolonged half-life and reduced effect on global coagulation and bleeding parameters. Due to the presence of both glycosaminoglycan fractions, sulodexide potentiates the antiprotease activities of both antithrombin III and heparin cofactor II simultaneously.
Excerpted from Wikipedia’s “sulodexide” article, available under the CC BY-SA 4.0 licence.