GMDS
Sign in to saveAlso known as GMD, SDR3E1, GDP-mannose 4,6-dehydratase
protein-coding gene in the species Homo sapiens
In the Vinony graph
Vinony's link graph records 3 inbound references to GMDS, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 6.
Vinony links it to 5 Wikipedia language editions.
Gene data
GMDS- Name
- GDP-mannose 4,6-dehydratase
- Type
- protein-coding
- Position
- 1,622,884–2,245,711 (−)
- Aliases
- GMD, SDR3E1
- Ensembl
- ENSG00000112699
- RefSeq RNA
- NM_001253846.2, NM_001500.4, XM_006715066.4, XM_011514500.2, XM_011514502.4
- RefSeq protein
- NP_001240775.1, NP_001491.1, XP_006715129.1, XP_011512802.1, XP_011512804.1
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
GDP-mannose 4,6-dehydratase
- Symbol
- GMDS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:1,622,884-2,245,711
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein GMDS PDB 1t2a.png
Show 8 more facts
- HomoloGene ID
- 75968
- cytogenetic location
- 6p25.3
- chromosome
- human chromosome 6
- genetic association
- obesity
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2762
- genomic end
- 2245605
- genomic start
- 1624041
via Wikidata · CC0