GNLY
Sign in to saveAlso known as 519, D2S69E, LAG-2, LAG2, NKG5, TLA519, granulysin
Granulysin (GNLY) is a protein expressed in most mammals which functions as an antimicrobial peptide released by killer lymphocytes in cytotoxic granules. It is a pore-forming peptide, as it can puncture a microbial cell wall, allowing for other death-inducing enzymes to enter the microbe and cause microptosis. GNLY is inhibited by cholesterol, and is most effective in helping to kill cholesterol-deficient microbes.
Gene data
GNLY- Name
- granulysin
- Type
- protein-coding
- Aliases
- D2S69E, LAG-2, LAG2, NKG5, TLA519
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
- Image
- Protein GNLY PDB 1l9l.png
Show 5 more facts
- exact match
- identifiers.org/ncbigene/10578
- HomoloGene ID
- 136805
- genomic end
- 85698852
- genomic start
- 85912298
- cytogenetic location
- 2p11.2
via Wikidata · CC0
~8 min read
Article
11 sectionsContents
- Structure
- Gene expression
- Function
- 15 kDa GNLY
- 9 kDa GNLY
- Evolution
- Clinical significance
- Toxic epidermal necrolysis
- Cancer
- References
- Further reading
Granulysin (GNLY) is a protein expressed in most mammals which functions as an antimicrobial peptide released by killer lymphocytes in cytotoxic granules. It is a pore-forming peptide, as it can puncture a microbial cell wall, allowing for other death-inducing enzymes to enter the microbe and cause microptosis. GNLY is inhibited by cholesterol, and is most effective in helping to kill cholesterol-deficient microbes.
It is part of the saposin-like protein family and contains saposin protein domain, and its gene is found on the 2nd chromosome in humans. It is distinguished by its 5 α-helical structure. Its expression is restricted to cytotoxic immune cells such as cytotoxic T cells, NK cells, NKT cells and γδ T cells. Orthologs of this protein are found in most mammal species, such as in cows and pigs, however not in rodents.
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