GNLY
Sign in to saveAlso known as 519, D2S69E, LAG-2, LAG2, NKG5, TLA519, granulysin
Granulysin (GNLY) is a protein expressed in most mammals which functions as an antimicrobial peptide released by killer lymphocytes in cytotoxic granules. It is a pore-forming peptide, as it can puncture a microbial cell wall, allowing for other death-inducing enzymes to enter the microbe and cause microptosis. GNLY is inhibited by cholesterol, and is most effective in helping to kill cholesterol-deficient microbes.
In the Vinony graph
Within Vinony's link graph, GNLY is referenced by 20 other articles, and connects out to mitochondrion, PubMed and human chromosome 2.
It is catalogued under the topic Genes on human chromosome 2.
Its subject is documented across 9 Wikipedia language editions.
Gene data
GNLY- Name
- granulysin
- Type
- protein-coding
- Position
- 85,685,175–85,698,854 (+)
- Aliases
- D2S69E, LAG-2, LAG2, NKG5, TLA519
- Ensembl
- ENSG00000115523
- RefSeq RNA
- NM_001302758.2, NM_006433.5, NM_012483.4, XM_005264084.3, XM_005264085.3
- RefSeq protein
- NP_001289687.1, NP_006424.2, NP_036615.2, XP_005264141.1, XP_005264142.1
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
granulysin
- Symbol
- GNLY
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:85,685,175-85,698,854
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein GNLY PDB 1l9l.png
Show 7 more facts
- exact match
- identifiers.org/ncbigene/10578
- HomoloGene ID
- 136805
- found in taxon
- Homo sapiens
- genomic end
- 85698852
- genomic start
- 85912298
- chromosome
- human chromosome 2
- cytogenetic location
- 2p11.2
via Wikidata · CC0
~8 min read
Encyclopedic overview
11 sectionsContents
- Structure
- Gene expression
- Function
- 15 kDa GNLY
- 9 kDa GNLY
- Evolution
- Clinical significance
- Toxic epidermal necrolysis
- Cancer
- References
- Further reading
Granulysin (GNLY) is a protein expressed in most mammals which functions as an antimicrobial peptide released by killer lymphocytes in cytotoxic granules. It is a pore-forming peptide, as it can puncture a microbial cell wall, allowing for other death-inducing enzymes to enter the microbe and cause microptosis. GNLY is inhibited by cholesterol, and is most effective in helping to kill cholesterol-deficient microbes.
It is part of the saposin-like protein family and contains saposin protein domain, and its gene is found on the 2nd chromosome in humans. It is distinguished by its 5 α-helical structure. Its expression is restricted to cytotoxic immune cells such as cytotoxic T cells, NK cells, NKT cells and γδ T cells. Orthologs of this protein are found in most mammal species, such as in cows and pigs, however not in rodents.
Excerpted from Wikipedia’s “GNLY” article, available under the CC BY-SA 4.0 licence.
Available in 9 languages
via Wikidata sitelinks · CC0