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GeneQ15316535· pop 5· linked from 493 articles

GNRHR

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Also known as GNRHR1, GRHR, HH7, LHRHR, LRHR, gonadotropin releasing hormone receptor

Gonadotropin-releasing hormone receptor is a protein that in humans is encoded by the GNRHR gene.

Gene data

GNRHR
Name
gonadotropin releasing hormone receptor
Type
protein-coding
Position
67,737,118–67,754,403 (−)
Aliases
GNRHR1, GRHR, HH7, LHRHR, LRHR
Ensembl
ENSG00000109163
RefSeq RNA
NM_000406.3, NM_001012763.2
RefSeq protein
NP_000397.1, NP_001012781.1

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Neuroactive ligand-receptor interaction - Homo sapiens (human)GnRH signaling pathway - Homo sapiens (human)Signal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)Hormone ligand-binding receptorsGPCR downstream signallingG alpha (q) signalling eventsGPCR ligand bindingGPCRs, Other

via MyGene.info

Gene · Ensembl

gonadotropin releasing hormone receptor

Symbol
GNRHR
Biotype
Protein coding
Organism
Homo sapiens
Location
4:67,737,118-67,754,403
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

4 sections
Contents
  • See also
  • References
  • Further reading
  • External links

Gonadotropin-releasing hormone receptor is a protein that in humans is encoded by the GNRHR gene.

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Excerpted from Wikipedia’s “GNRHR” article, available under the CC BY-SA 4.0 licence.

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