GRB14

Also known as growth factor receptor bound protein 14

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.

Gene data

GRB14

Name: growth factor receptor bound protein 14
Type: protein-coding
Position: 164,492,417–164,622,472 (−)
Ensembl: ENSG00000115290
RefSeq RNA: NM_001303422.2, NM_004490.3, XM_011511022.2, XM_047444013.1, XM_047444014.1
RefSeq protein: NP_001290351.1, NP_004481.2, XP_011509324.1, XP_047299969.1, XP_047299970.1

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

Gene Ontology

Biological process

signal transduction signal transduction insulin receptor signaling pathway intracellular signal transduction negative regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway

Molecular function

protein binding protein-macromolecule adaptor activity protein-macromolecule adaptor activity receptor tyrosine kinase binding molecular adaptor activity

Cellular component

cytoplasm cytoplasm cytoplasm cytosol plasma membrane plasma membrane endosome membrane

Pathways

Hemostasis Cell surface interactions at the vascular wall Tie2 Signaling RAC1-PAK1-p38-MMP2 Pathway Insulin Signaling

via MyGene.info

Wikidata facts

Image: Protein GRB14 PDB 2aug.png

Show 6 more facts

HomoloGene ID: 3303
exact match: identifiers.org/ncbigene/2888
genomic end: 164621482
genomic start: 164492417
cytogenetic location: 2q24.3
Commons category: Growth factor receptor-bound protein 14 (GRB14)

Sources (3)

via Wikidata · CC0

~1 min read

Article

3 sections

Contents

Interactions
References
Further reading

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.