File:Haloperidol.svg · Wikimedia Commons · See Wikimedia Commons
haloperidol
Sign in to saveAlso known as Haloperidolum, Haldol®, MCN-JR-1625, R-1625, Serenace®, gamma-(4-(p-chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal. It may be used by mouth or injection into a muscle or a vein. Haloperidol typically works within 30 to 60 minutes. A long-acting formulation may be used as an injection every four weeks for people with schizophrenia or related illnesses, who either forget or refuse to take the medication by mouth.
OverviewAI-generated
Haloperidol is a chemical compound with the formula C₂₁H₂₃ClFNO₂. Its IUPAC name is 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one. The substance has a mass of 375.140135 and a weight of 375.9. It possesses a defined daily dose of 8.
Chemical properties include an xlogp of 3.2 and a topological polar surface area of 40.5. The molecule contains one hydrogen bond donor and four hydrogen bond acceptors, with a charge of 0. It is assigned the MCN code 2933.39.15.
In scientific literature, haloperidol is the subject of 24,000 PubMed entries. The compound is referenced by 3,093 other encyclopedia articles.
Synthesized by Vinony from 19 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.KEGG
- D00136
- Drug.ChEBI
- 5613
- Drug.ChEMBL
- 54
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464369120
- Drug.image
- Haloperidol.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250px
- Drug.image2
- Haloperidol-from-xtal-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250px
- Drug.tradename
- Haldol, others
- Drug.MedlinePlus
- a682180
- Drug.DailyMedID
- Haloperidol
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth, intramuscular, intravenous, depot (as decanoate ester)
- Drug.class
- Typical antipsychotic
- Drug.ATC_prefix
- N05
via Wikipedia infobox
Chemical data
- Formula
- C21H23ClFNO2
- Molecular weight
- 375.9 g/mol
- IUPAC name
- 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
- SMILES
- C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
- InChIKey
- LNEPOXFFQSENCJ-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 40.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
24,000 papersvia PubMed
~19 min read
Encyclopedic overview
28 sectionsContents
- Medical uses
- Pregnancy and lactation
- Other considerations
- Adverse effects
- Contraindications
- Special cautions
- Interactions
- Potential neurotoxicity
- Discontinuation
- Overdose
- Symptoms
- Treatment
- Prognosis
- Pharmacology
- Pharmacokinetics
- By mouth
- Intramuscular injections
- Intravenous injections
- Therapeutic concentrations
- Distribution and metabolism
- Chemistry
- History
- Society and culture
- Cost
- Names
- Research
- Veterinary use
- References
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal. It may be used by mouth or injection into a muscle or a vein. Haloperidol typically works within 30 to 60 minutes. A long-acting formulation may be used as an injection every four weeks for people with schizophrenia or related illnesses, who either forget or refuse to take the medication by mouth.
Haloperidol may result in movement disorders such as tardive dyskinesia, and akathisia, both of which may be permanent. Neuroleptic malignant syndrome and QT interval prolongation may occur, the latter particularly with IV administration. In older people with psychosis due to dementia it results in an increased risk of death. When taken during pregnancy it may result in problems in the infant. It should not be used by people with Parkinson's disease.
Excerpted from Wikipedia’s “haloperidol” article, available under the CC BY-SA 4.0 licence.