β-Globin
Sign in to saveAlso known as hemoglobin beta subunit, beta globin chain, hemoglobin, beta, Beta-globin, Hemoglobin beta chain, HBB, hemoglobin subunit beta
Protein
Protein · UniProt
Hemoglobin subunit beta
- Gene
- HBB
- Organism
- Homo sapiens (Human)
- Length
- 147 aa
- Molecular mass
- 15,998 Da
- Evidence
- 1: Evidence at protein level
Involved in oxygen transport from the lung to the various peripheral tissues
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
8 registered- PHASE1/PHASE2RECRUITINGAn Open-label Study of a Gene Therapy Product (Vebeglogene Autotemcel) in Transfusion Dependent Beta-ThalassemiaLantu Biopharma · NCT06308159
- COMPLETEDDemographic, Clinical, Laboratory and Genetical Characteristics of Patients With Beta Thalassemia IntermediaHaEmek Medical Center, Israel · NCT01443312
- PHASE1/PHASE2COMPLETEDStem Cell Gene Therapy for Sickle Cell DiseaseDonald B. Kohn, M.D. · NCT02247843
- PHASE1/PHASE2RECRUITINGEfficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.Assistance Publique - Hôpitaux de Paris · NCT07432867
- PHASE1/PHASE2UNKNOWNGene Therapy for Transfusion Dependent Beta-thalassemiaIRCCS San Raffaele · NCT02453477
- PHASE1RECRUITINGSingle-dose Pharmacokinetics of Pociredir in Participants With Sickle Cell DiseaseFulcrum Therapeutics · NCT07431398
Wikidata facts
- Instance of
- protein
Show 3 more facts
- cell component
- extracellular space
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P68871
Sources (3)
via Wikidata · CC0
Article · Deutsch
β-Globin, beta-Globin, oder Hämoglobin beta-Kette ist ein Protein aus der Familie der Globine, dessen 147 Aminosäuren lange Polypeptidkette ein Häm als Cofaktor bindet und das so als Hämoglobin-Untereinheit beta (HBB) Teil von Hämoglobin-Proteinkomplexen in Wirbeltieren ist. Beim erwachsenen Menschen wird für den Sauerstofftransport als häufigste Form des Hämoglobins ein Tetramer aus zwei beta- und zwei alpha-Ketten (HBA) gebildet, das sogenannte adulte Hämoglobin A (HbA(1) – α2β2).
Abstract from DBpedia / Wikipedia · CC BY-SA