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histiocyte
Sign in to saveAlso known as histiocytes, fixed macrophage, connective tissue macrophage
thumb | right | alt=Representative photographs of an open biopsy specimen (400x): a. Necrosis, usually with blurred cell shadow, was mixed with karyorrhexis and histiocytes. b. Numerous histiocytes engulfed karyorrhectic debris. c. Foamy histiocytes were identified. d. Immunohistochemical stain for CD123 highlighted plasmacytoid dendritic cells. Hematoxylin counterstain revealed abundant karyorrhexis around the plasmacytoid dendritic cells. | Representative photographs of an open biopsy specimen (400x): a. Necrosis, usually with blurred cell shadow, was mixed with karyorrhexis and histiocytes.
Key facts
- Cell.Name
- Histiocyte
- Cell.Latin
- macrophagocytus immobilis
- Cell.System
- Immune system
via Wikipedia infobox
Research
20,117 papers- Histiocyte Society blueprint for hemophagocytic lymphohistiocytosis research: deciphering underlying disease mechanisms to optimize diagnosis and therapy.Haematologica · 2025
- Histiocyte Society blueprint for non-Langerhans cell histiocytosis research: unraveling complex diseases through collaboration.Haematologica · 2025
- Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses.Virchows Archiv : an international journal of pathology · 2021
- Rosai-Dorfman disease: an overview.Journal of clinical pathology · 2020
- T-cell/histiocyte-rich large B-cell lymphoma in the era of novel immunotherapy: A focused review.British journal of haematology · 2026
via PubMed
Wikidata facts
Show 1 more fact
- native label
- macrophagocytus immobilis
Sources (2)
via Wikidata · CC0
~5 min read
Article
7 sectionsContents
- Development
- Structure
- Macrophages and dendritic cells
- Langerhans cells
- Clinical significance
- See also
- References
thumb | right | alt=Representative photographs of an open biopsy specimen (400x): a. Necrosis, usually with blurred cell shadow, was mixed with karyorrhexis and histiocytes. b. Numerous histiocytes engulfed karyorrhectic debris. c. Foamy histiocytes were identified. d. Immunohistochemical stain for CD123 highlighted plasmacytoid dendritic cells. Hematoxylin counterstain revealed abundant karyorrhexis around the plasmacytoid dendritic cells. | Representative photographs of an open biopsy specimen (400x): a. Necrosis, usually with blurred cell shadow, was mixed with karyorrhexis and histiocytes. b. Numerous histiocytes engulfed karyorrhectic debris. c. Foamy histiocytes were identified. d. Immunohistochemical stain for CD123 highlighted plasmacytoid dendritic cells. Hematoxylin counterstain revealed abundant karyorrhexis around the plasmacytoid dendritic cells. A histiocyte is a vertebrate cell that is part of the mononuclear phagocyte system (also known as the reticuloendothelial system or lymphoreticular system). The mononuclear phagocytic system is part of the organism's immune system. The histiocyte is a tissue macrophage or a dendritic cell (histio, diminutive of histo, meaning tissue, and cyte, meaning cell). Part of their job is to clear out neutrophils once they've reached the end of their lifespan.
==Development== Histiocytes are derived from the bone marrow by multiplication from a stem cell. The derived cells migrate from the bone marrow to the blood as monocytes. They circulate through the body and enter various organs, where they undergo differentiation into histiocytes, which are part of the mononuclear phagocytic system (MPS).