hydromorphinol
Sign in to saveHydromorphinol (RAM-320, 14-hydroxydihydromorphine), is an opiate analogue that is a derivative of morphine, where the 14-position has been hydroxylated and the 7,8- double bond saturated. It has similar effects to morphine such as sedation, analgesia and respiratory depression, but is twice as potent as morphine and has a steeper dose-response curve and longer half-life. It is used in medicine as the bitartrate salt (free base conversion ratio 0.643, molecular weight 471.5) and hydrochloride (free base conversion ratio 0.770, molecular weight 393.9)
Wikidata facts
- Mass
- 303.147
Show 3 more facts
- chemical formula
- C₁₇H₂₁NO₄
- canonical SMILES
- CN1CCC23C4C(CCC2(C1CC5=C3C(=C(C=C5)O)O4)O)O
- isomeric SMILES
- CN1CC[C@]23[C@@H]4[C@H](CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O)O
Sources (2)
via Wikidata · CC0
~2 min read
Article
2 sectionsContents
- See also
- References
Hydromorphinol (RAM-320, 14-hydroxydihydromorphine), is an opiate analogue that is a derivative of morphine, where the 14-position has been hydroxylated and the 7,8- double bond saturated. It has similar effects to morphine such as sedation, analgesia and respiratory depression, but is twice as potent as morphine and has a steeper dose-response curve and longer half-life. It is used in medicine as the bitartrate salt (free base conversion ratio 0.643, molecular weight 471.5) and hydrochloride (free base conversion ratio 0.770, molecular weight 393.9)
Hydromorphinol has also been discovered to occur naturally in trace amounts within opium, although this is a very rare occurrence.