ICOS
Sign in to saveAlso known as AILIM, CD278, CVID1, inducible T-cell co-stimulator, inducible T-cell costimulator, inducible T cell costimulator
Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (Inducible T-cell COStimulator) gene. The protein belongs to the CD28 and CTLA-4 cell-surface receptor family. These are proteins expressed on the surface of immune cells that mediate signalling between them. A surface protein, the ligand, binds specifically to its receptor on another cell, leading to a signalling cascade in that cell.
Gene data
ICOS- Name
- inducible T cell costimulator
- Type
- protein-coding
- Position
- 203,936,757–203,961,577 (+)
- Aliases
- AILIM, CD278, CVID1
- Ensembl
- ENSG00000163600
- RefSeq RNA
- NM_012092.4, XM_047444022.1, XM_054341553.1, XR_007073112.1, XR_008486351.1
- RefSeq protein
- NP_036224.1, XP_047299978.1, XP_054197528.1
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
inducible T cell costimulator
- Symbol
- ICOS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:203,936,757-203,961,577
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 8097
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/29851
- genomic end
- 204826300
- genomic start
- 203936763
- chromosome
- human chromosome 2
- cytogenetic location
- 2q33.2
- expressed in
- tonsil
Sources (4)
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Function
- Knockout phenotype
- Combination therapy
- References
- Further reading
- External links
Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (Inducible T-cell COStimulator) gene.
The protein belongs to the CD28 and CTLA-4 cell-surface receptor family. These are proteins expressed on the surface of immune cells that mediate signalling between them. A surface protein, the ligand, binds specifically to its receptor on another cell, leading to a signalling cascade in that cell.
Excerpted from Wikipedia’s “ICOS” article, available under the CC BY-SA 4.0 licence.