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GeneQ18031519· pop 6· linked from 371 articles

SLAMF1

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Also known as CD150, CDw150, SLAM, signaling lymphocytic activation molecule family member 1

Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene. Recently SLAMF1 has also been designated CD150 (cluster of differentiation 150).

Gene data

SLAMF1
Name
signaling lymphocytic activation molecule family member 1
Type
protein-coding
Position
160,608,100–160,647,056 (−)
Aliases
CD150, CDw150, IPO3, SLAM
Ensembl
ENSG00000117090
RefSeq RNA
NM_001330754.2, NM_003037.5, NR_104399.3, NR_104400.3, NR_104401.3
RefSeq protein
NP_001317683.1, NP_003028.1, XP_005245513.1, XP_016857619.1, XP_016857620.1

Enables SH2 domain binding activity and identical protein binding activity. Involved in several processes, including negative regulation of CD40 signaling pathway; negative regulation of cytokine production; and positive regulation of MAPK cascade. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Pathways

Measles - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

signaling lymphocytic activation molecule family member 1

Symbol
SLAMF1
Biotype
Protein coding
Organism
Homo sapiens
Location
1:160,608,100-160,647,056
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~6 min read

Encyclopedic overview

10 sections
Contents
  • Gene
  • Structure
  • Signaling
  • Function
  • Role of SLAMF1 in diseases
  • Viral infections
  • Cancer
  • References
  • Further reading
  • External links

Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene. Recently SLAMF1 has also been designated CD150 (cluster of differentiation 150).

SLAMF1 belongs to the signaling lymphocytic activation molecule family. As other receptors from this family, SLAMF1 is expressed in different types of hematopoietic cells and it plays a role in the regulation of the immune system.

Excerpted from Wikipedia’s “SLAMF1” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0