IGF2

Name

insulin like growth factor 2

Type

protein-coding

Position

2,129,112–2,158,596 (−)

Aliases

C11orf43, GRDF, IGF-II, PP9974, SRS3

Ensembl

ENSG00000167244

RefSeq RNA

NM_000612.6, NM_001007139.6, NM_001127598.3, NM_001291861.3, NM_001291862.3

RefSeq protein

NP_000603.1, NP_001007140.2, NP_001121070.1, NP_001278790.1, NP_001278791.1

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

via MyGene.info

Gene · Ensembl

insulin like growth factor 2

Symbol

IGF2

Biotype

Protein coding

Organism

Homo sapiens

Location

11:2,129,112-2,158,596

Strand

Reverse (−)

Assembly

GRCh38

Protein · UniProt

Insulin-like growth factor 2

Gene

Igf2

Organism

Mus musculus (Mouse)

Length

180 aa

Molecular mass

20,030 Da

Evidence

1: Evidence at protein level

The insulin-like growth factors possess growth-promoting activity (PubMed:29440408). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed:12087403, PubMed:2330056). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). Positively regulates myogenic transcription factor MYOD1 function by facilitating …

Wikidata facts

Instance of

protein

Subclass of

protein

Image

Protein IGF2 PDB 1igl.png

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