IGF2
Sign in to saveAlso known as C11orf43, GRDF, IGF-II, PP9974, insulin like growth factor 2, SRS3, Insulin-like growth factor 2, multiplication-stimulating polypeptide
gène de l'espèce Homo sapiens
Gene data
IGF2- Name
- insulin like growth factor 2
- Type
- protein-coding
- Position
- 2,129,112–2,158,596 (−)
- Aliases
- C11orf43, GRDF, IGF-II, PP9974, SRS3
- Ensembl
- ENSG00000167244
- RefSeq RNA
- NM_000612.6, NM_001007139.6, NM_001127598.3, NM_001291861.3, NM_001291862.3
- RefSeq protein
- NP_000603.1, NP_001007140.2, NP_001121070.1, NP_001278790.1, NP_001278791.1
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
insulin like growth factor 2
- Symbol
- IGF2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:2,129,112-2,158,596
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Protein · UniProt
Insulin-like growth factor 2
- Gene
- Igf2
- Organism
- Mus musculus (Mouse)
- Length
- 180 aa
- Molecular mass
- 20,030 Da
- Evidence
- 1: Evidence at protein level
The insulin-like growth factors possess growth-promoting activity (PubMed:29440408). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed:12087403, PubMed:2330056). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). Positively regulates myogenic transcription factor MYOD1 function by facilitating …
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
Show 10 more facts
- HomoloGene ID
- 510
- found in taxon
- house mouse
- exact match
- identifiers.org/ncbigene/3481
- cytogenetic location
- 11p15.5
- genetic association
- Silver-Russell syndrome
- chromosome
- human chromosome 11
- genomic start
- 2150342
- genomic end
- 2158391
- expressed in
- left ventricle
- Commons category
- Insulin-like growth factor II
via Wikidata · CC0
Article · Français
L'IGF-2, de l'anglais insulin-like growth factor 2 (aussi appelée somatomédine A) est une hormone peptidique présentant des similarités structurelles avec l'insuline. Elle est normalement sécrétée par le foie et possède des propriétés hypoglycémiantes, mitogènes, et régulatrices de croissance. C'est un facteur de croissance important chez le fœtus, tout comme l'IGF-1 est un facteur de croissance chez l'adulte. Son gène est situé sur le chromosome 11p15.5. L'IGF-2 peut être sécrété de manière anormale par les tumeurs fibreuses solitaires et est alors responsable d'un syndrome de Doege-Potter. Il est également impliqué dans le syndrome de Silver-Russell, les rhabdomyosarcomes et les tumeurs de Wilms.
Abstract from DBpedia / Wikipedia · CC BY-SA