Interleukin 2 receptor subunit alpha
Sign in to saveAlso known as TAC antigen, interleukin-2 receptor subunit alpha, p55, IL-2 receptor subunit alpha, IL2RA, IL-2R subunit alpha, interleukin 2 receptor, alpha, CD25
The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with interleukin-2, a pleiotropic cytokine which plays an important role in immune homeostasis.
Protein · UniProt
Interleukin-2 receptor subunit alpha
- Gene
- IL2RA
- Organism
- Homo sapiens (Human)
- Length
- 272 aa
- Molecular mass
- 30,819 Da
- Evidence
- 1: Evidence at protein level
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
4 registered- PHASE1/PHASE2RECRUITINGStudy of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic CancerAulos Bioscience, Inc. · NCT05267626
- PHASE2COMPLETEDZenapax (Daclizumab) to Treat Relapsing Remitting Multiple SclerosisNational Institute of Neurological Disorders and Stroke (NINDS) · NCT00071838
- PHASE2COMPLETEDZenapax to Treat Multiple SclerosisNational Institute of Neurological Disorders and Stroke (NINDS) · NCT00001934
- PHASE1/PHASE2RECRUITINGA First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their BodyRegeneron Pharmaceuticals · NCT06413680
Wikidata facts
- Instance of
- protein
Show 1 more fact
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~9 min read
Encyclopedic overview
10 sectionsContents
- Genetics
- Expression
- Structure
- Signalling cascade of interleukin-2 receptor
- Clinical significance
- CD25 as a biomarker
- CD25 as a therapeutic target
- References
- Further reading
- External links
The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with interleukin-2, a pleiotropic cytokine which plays an important role in immune homeostasis.
== Genetics == The human protein interleukin-2 receptor subunit alpha is encoded by a gene called IL2RA with a length around 51,6 kb. Alternative names for this protein coding gene are IL2R, IDDM10 and TCGFR. Location of IL2RA in human genome is on the short arm of 10th chromosome (10p15.1).
Excerpted from Wikipedia’s “Interleukin 2 receptor subunit alpha” article, available under the CC BY-SA 4.0 licence.