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GeneQ18033889· pop 5· linked from 167 articles

IL1RL1

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Also known as DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1, interleukin 1 receptor like 1

Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that in humans is encoded by the IL1RL1 gene.

Gene data

IL1RL1
Name
interleukin 1 receptor like 1
Type
protein-coding
Position
102,311,502–102,355,365 (+)
Aliases
DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1
Ensembl
ENSG00000115602
RefSeq RNA
NM_001282408.2, NM_003856.4, NM_016232.5, NM_173459.1, NR_104167.2
RefSeq protein
NP_001269337.1, NP_003847.2, NP_057316.3, XP_006712902.1, XP_011510453.1

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)PIP3 activates AKT signalingCytokine Signaling in Immune systemSignal TransductionImmune SystemNegative regulation of the PI3K/AKT networkInterleukin-1 family signalingSignaling by InterleukinsPI5P, PP2A and IER3 Regulate PI3K/AKT SignalingIntracellular signaling by second messengers

via MyGene.info

Gene · Ensembl

interleukin 1 receptor like 1

Symbol
IL1RL1
Biotype
Protein coding
Organism
Homo sapiens
Location
2:102,311,502-102,355,365
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
ST2 prot.png
Show 9 more facts
HomoloGene ID
2862
genetic association
asthma
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/9173
genomic end
102968497
genomic start
102927962
chromosome
human chromosome 2
cytogenetic location
2q12.1
expressed in
body of stomach
Sources (6)

via Wikidata · CC0

~5 min read

Encyclopedic overview

6 sections
Contents
  • Function
  • Molecular biology
  • Regulatory T cells
  • Clinical significance
  • References
  • Further reading

Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that in humans is encoded by the IL1RL1 gene.

== Function ==

Excerpted from Wikipedia’s “IL1RL1” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0