IL5RA

Also known as CD125, CDw125, HSIL5R3, IL5R, Interleukin 5 receptor alpha subunit, interleukin 5 receptor subunit alpha

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 437 inbound references to IL5RA, and connects out to Q180686, Interleukin 2 and Ensembl genome database project.

It is catalogued under topics including Clusters of differentiation and Genes on human chromosome 3.

Vinony links it to 5 Wikipedia language editions.

Gene data

IL5RA

Name: interleukin 5 receptor subunit alpha
Type: protein-coding
Position: 3,066,324–3,126,613 (−)
Aliases: CD125, CDw125, HSIL5R3, IL5R
Ensembl: ENSG00000091181
RefSeq RNA: NM_000564.5, NM_001243099.2, NM_175724.2, NM_175725.3, NM_175726.4
RefSeq protein: NP_000555.2, NP_001230028.1, NP_783851.1, NP_783852.1, NP_783853.1

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011].