IL5RA

Name

interleukin 5 receptor subunit alpha

Type

protein-coding

Position

3,066,324–3,126,613 (−)

Aliases

CD125, CDw125, HSIL5R3, IL5R

Ensembl

ENSG00000091181

RefSeq RNA

NM_000564.5, NM_001243099.2, NM_175724.2, NM_175725.3, NM_175726.4

RefSeq protein

NP_000555.2, NP_001230028.1, NP_783851.1, NP_783852.1, NP_783853.1

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011].

via MyGene.info

Gene · Ensembl

interleukin 5 receptor subunit alpha

Symbol

IL5RA

Biotype

Protein coding

Organism

Homo sapiens

Location

3:3,066,324-3,126,613

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

PDB 1obx EBI.jpg

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