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GeneQ14907251· pop 9· linked from 271 articles

IL25

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Also known as IL17E, IL-25, interleukin 25

protein-coding gene in the species Homo sapiens

Gene data

IL25

Name: interleukin 25
Type: protein-coding
Position: 23,372,809–23,376,403 (+)
Aliases: IL17E
Ensembl: ENSG00000166090
RefSeq RNA: NM_022789.4, NM_172314.2
RefSeq protein: NP_073626.1, NP_758525.1

The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].

Gene Ontology

Biological process

inflammatory response to antigenic stimulus regulation of keratinocyte proliferation protein K63-linked ubiquitination T-helper 17 type immune response interleukin-17-mediated signaling pathway

Molecular function

cytokine activity protein binding interleukin-17E receptor binding

Cellular component

extracellular region extracellular region plasma membrane

Pathways

Cytokine-cytokine receptor interaction - Homo sapiens (human)IL-17 signaling pathway - Homo sapiens (human)Cytokine Signaling in Immune system Immune System Interleukin-17 signaling Signaling by Interleukins IL17 signaling pathway Vitamin D Receptor Pathway Development and heterogeneity of the ILC family

via MyGene.info

Gene · Ensembl

interleukin 25

Symbol: IL25
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:23,372,809-23,376,403
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

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