File:Indometacin_skeletal_formula_from_xtal_2003.svg · Wikimedia Commons · See Wikimedia Commons
indomethacin
Sign in to saveAlso known as Indocid®, Indocin®, 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid, Indometacina, {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid, Indometacinum, Aconip
Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase, an enzyme that catalyzes the production of prostaglandins.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 460769466
- Drug.image
- Indometacin skeletal formula from xtal 2003.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 225
- Drug.image2
- Indometacin-from-xtal-2003-ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.USAN
- Indomethacin
- Drug.tradename
- Indocid, Indocin
- Drug.DailyMedID
- Indomethacin
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth, rectal, intravenous, topical
- Drug.ATC_prefix
- C01
- Drug.ATC_suffix
- EB03
- Drug.ATC_supplemental
- , ,
- Drug.legal_AU
- Schedule 4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
via Wikipedia infobox
Chemical data
- Formula
- C19H16ClNO4
- Molecular weight
- 357.8 g/mol
- IUPAC name
- 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
- SMILES
- CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
- InChIKey
- CGIGDMFJXJATDK-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 68.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- indole alkaloid
- Has part
- chlorine
- Mass
- 357.077
- Manufacturer
- Pfizer
- Has use
- medication
Show 11 more facts
- medical condition treated
- inflammation
- chemical formula
- C₁₉H₁₆ClNO₄
- found in taxon
- Aspergillus
- canonical SMILES
- CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
- World Health Organisation international non-proprietary name
- indometacin
- subject has role
- tocolytic uterine relaxants
- physically interacts with
- solute carrier family 46 member 1
- melting point
- 160
- Commons category
- Indometacin
- legal status (medicine)
- boxed warning
- significant drug interaction
- furosemide
Sources (6)
via Wikidata · CC0
~13 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Pharmacology
- Mechanism of action
- Society and culture
- Names
- References
{{Infobox drug | Watchedfields = changed | verifiedrevid = 460769466 | image = Indometacin skeletal formula from xtal 2003.svg | image_class = skin-invert-image | width = 225 | alt = | image2 = Indometacin-from-xtal-2003-ball-and-stick.png | image_class2 = bg-transparent | alt2 = | USAN = Indomethacin
| pronounce = | tradename = Indocid, Indocin | DailyMedID = Indomethacin | Drugs.com = | pregnancy_AU = C | pregnancy_category = | routes_of_administration = By mouth, rectal, intravenous, topical | ATC_prefix = C01 | ATC_suffix = EB03 | ATC_supplemental = , ,
Excerpted from Wikipedia’s “indomethacin” article, available under the CC BY-SA 4.0 licence.