integrin subunit alpha 3
Sign in to saveAlso known as alpha 3 subunit of VLA-3 receptor, integrin alpha-3, CD49 antigen-like family member C, testicular tissue protein Li 98, very late activation protein 3 receptor, alpha-3 subunit, testicular tissue protein Li 96, GAPB3, integrin alpha 3
mammalian protein found in Homo sapiens
Protein · UniProt
Integrin alpha-3
- Gene
- ITGA3
- Organism
- Homo sapiens (Human)
- Length
- 1,051 aa
- Molecular mass
- 116,612 Da
- Evidence
- 1: Evidence at protein level
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration
Swiss-Prot (reviewed) · via UniProt
Research
77 papers- Exosomal integrin alpha 3 promotes epithelial ovarian cancer cell migration via the S100A7/p-ERK signaling pathway.Acta biochimica et biophysica Sinica · 2025
- Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer.Open medicine (Warsaw, Poland) · 2022
- Metastasis and basement membrane-related signature enhances hepatocellular carcinoma prognosis and diagnosis by integrating single-cell RNA sequencing analysis and immune microenvironment assessment.Journal of translational medicine · 2024
- Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431.Molecular & cellular proteomics : MCP · 2014
- ITGA3-MET interaction promotes papillary thyroid cancer progression via ERK and PI3K/AKT pathways.Annals of medicine · 2025
via PubMed