integrin subunit alpha 6

Also known as CD49 antigen-like family member F, ITGA6, integrin alpha-6, Very Late Antigen-6, integrin, alpha 6, integrin alpha6B, VLA-6, Integrin alpha6

mammalian protein found in Homo sapiens

Protein · UniProt

Integrin alpha-6

Gene: ITGA6
Organism: Homo sapiens (Human)
Length: 1,130 aa
Molecular mass: 126,606 Da
Evidence: 1: Evidence at protein level

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds …

3D-structureAlternative splicingCalciumCell adhesionCell membraneCleavage on pair of basic residuesDirect protein sequencingDisulfide bond

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Swiss-Prot (reviewed) · via UniProt