Image by ChiemSeherin on Pixabay · Pixabay License
Integrin subunit alpha L
Sign in to saveAlso known as leukocyte function-associated molecule 1 alpha chain, ITGAL, antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide, CD11 antigen-like family member A, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), lymphocyte function-associated antigen 1, alpha polypeptide, LFA-1A, leukocyte adhesion glycoprotein LFA-1 alpha chain
mammalian protein found in Homo sapiens
Protein · UniProt
Integrin alpha-L
- Gene
- ITGAL
- Organism
- Homo sapiens (Human)
- Length
- 1,170 aa
- Molecular mass
- 128,770 Da
- Evidence
- 1: Evidence at protein level
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 (PubMed:10846180, PubMed:12526797, PubMed:1676048, PubMed:3086451). Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxici…
Swiss-Prot (reviewed) · via UniProt
Research
300 papers- A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence.Autophagy · 2022
- The Reactive Oxygen Species Scavenger N-Acetyl-L-Cysteine Reduces Storage-Dependent Decline in Integrin α (IIb) β (3)-Mediated Platelet Function, Inhibiting Pre-Activation of Integrin and Its β (3) Subunit Cleavage.Oxidative medicine and cellular longevity · 2025
- Cyclo(Arg-Gly-Asp-d-Tyr-Lys)-Cy5.5.2004
- Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence.Autophagy · 2021
- Cypate-Gly-Arg-Asp-Ser-Pro-Lys.2004
via PubMed