Structure via PubChem · Public domain (PubChem)
iobitridol
Sign in to saveAlso known as N,N'-bis(2,3-dihydroxypropyl)-5-(2-(hydroxymethyl)hydracrylamido)-2,4,6-triiodo-N,N'-dimethylisophthalamide
Iobitridol (trade name Xenetix) is a pharmaceutical drug used as an iodine-based radiocontrast agent in X-ray imaging. It is injected into blood vessels, joints, or body cavities such as the uterus, and filtered out by the kidneys. Its most common adverse effect is nausea. Severe allergic reactions are rare.
Chemical data
- Formula
- C20H28I3N3O9
- Molecular weight
- 835.2 g/mol
- IUPAC name
- 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[[3-hydroxy-2-(hydroxymethyl)propanoyl]amino]-2,4,6-triiodo-1-N,3-N-dimethylbenzene-1,3-dicarboxamide
- SMILES
- CN(CC(CO)O)C(=O)C1=C(C(=C(C(=C1I)NC(=O)C(CO)CO)I)C(=O)N(C)CC(CO)O)I
- InChIKey
- YLPBXIKWXNRACS-UHFFFAOYSA-N
- XLogP
- -3
- Polar surface area
- 191 Ų
- H-bond donors
- 7
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- Acute kidney injury
via ChEMBL · EBI
Research
252 papersvia PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 834.896
Show 4 more facts
- MCN code
- 2924.29.64
- chemical formula
- C₂₀H₂₈I₃N₃O₉
- canonical SMILES
- CN(CC(CO)O)C(=O)C1=C(C(=C(C(=C1I)NC(=O)C(CO)CO)I)C(=O)N(C)CC(CO)O)I
- subject has role
- contrast agent
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Overdose
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Chemistry
- References
Iobitridol (trade name Xenetix) is a pharmaceutical drug used as an iodine-based radiocontrast agent in X-ray imaging. It is injected into blood vessels, joints, or body cavities such as the uterus, and filtered out by the kidneys. Its most common adverse effect is nausea. Severe allergic reactions are rare.
The drug received its first marketing approval in 1994 in France and is approved for use in many European countries including the UK, but not in the US. It is manufactured by Guerbet.
Excerpted from Wikipedia’s “iobitridol” article, available under the CC BY-SA 4.0 licence.