IRAG1

Also known as IRAG, JAW1L, murine retrovirus integration site 1 homolog, MRVI1, inositol 1,4,5-triphosphate receptor associated 1

Protein MRVI1 is a protein that in humans is encoded by the MRVI1 gene.

Gene data

IRAG1

Name: inositol 1,4,5-triphosphate receptor associated 1
Type: protein-coding
Aliases: IRAG, JAW1L, MRVI1

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011].

via MyGene.info