IRF4

Name

interferon regulatory factor 4

Type

protein-coding

Position

391,739–411,443 (+)

Aliases

IMD131, LSIRF, MUM1, NF-EM5, SHEP8

Ensembl

ENSG00000137265

RefSeq RNA

NM_001195286.2, NM_002460.4, NR_036585.1, NR_046000.3, XM_006715090.3

RefSeq protein

NP_001182215.1, NP_002451.2, XP_006715153.1, XP_047274686.1, XP_054211324.1

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010].

via MyGene.info

Gene · Ensembl

interferon regulatory factor 4

Symbol

IRF4

Biotype

Protein coding

Organism

Homo sapiens

Location

6:391,739-411,443

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein IRF4 PDB 2dll.png

via Wikidata · CC0