IRF8
Sign in to saveAlso known as H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8, interferon regulatory factor 8
Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell.
Gene data
IRF8- Name
- interferon regulatory factor 8
- Type
- protein-coding
- Aliases
- H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
interferon regulatory factor 8
- Symbol
- IRF8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:85,899,116-85,922,606
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 1629
- exact match
- identifiers.org/ncbigene/3394
- genetic association
- Epstein–Barr virus infection
- found in taxon
- Homo sapiens
- genomic end
- 85922606
- genomic start
- 85899116
- chromosome
- human chromosome 16
- cytogenetic location
- 16q24.1
- expressed in
- rectum
via Wikidata · CC0
~3 min read
Encyclopedic overview
9 sectionsContents
- Function
- Knockout studies
- Clinical significance
- Interactions
- See also
- References
- Illustrations
- Further reading
- External links
Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a monocyte precursor cell.
== Function == Interferon Consensus Sequence-binding protein (ICSBP) is a transcription factor of the interferon regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-α and IFN-β. IRF family proteins also control expression of IFN-α and IFN-β-regulated genes that are induced by viral infection.
Excerpted from Wikipedia’s “IRF8” article, available under the CC BY-SA 4.0 licence.