Structure via PubChem · Public domain (PubChem)
Isosorbiddinitrat
Sign in to saveAlso known as Sorbitrate, Dilatrate, Isordil, Dilatrate-Sr, 3,6-Dianhydrosorbitol 2,5-dinitrate, Dianhydrosorbitol 2,5-dinitrate, Sorbidilat, Flindix
Arzneistoff
Chemical data
- Formula
- C6H8N2O8
- Molecular weight
- 236.14 g/mol
- IUPAC name
- [(3S,3aS,6R,6aS)-3-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate
- SMILES
- C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O[N+](=O)[O-])O[N+](=O)[O-]
- InChIKey
- MOYKHGMNXAOIAT-JGWLITMVSA-N
- XLogP
- 1.3
- Polar surface area
- 129 Ų
- H-bond donors
- 0
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1986
- Admin. routes
- oral, topical
- Indications
- cardiovascular disease, congestive heart failure, diabetic foot, Myocardial Ischemia
via ChEMBL · EBI
Research
4,440 papers- Long-acting isosorbide mononitrate.Drugs · 1999
- Isosorbide dinitrate.Minnesota medicine · 1983
- Role of isosorbide dinitrate in management of chronic congestive heart failure.American heart journal · 1985
- Isosorbide dinitrate pharmacokinetics.Arzneimittel-Forschung · 1982
- Duration of action of isosorbide dinitrate.Chest · 1979
via PubMed
Wikidata facts
- Subclass of
- nitrate
- Mass
- 236.028065
- Has use
- medication
Show 8 more facts
- chemical formula
- C₆H₈N₂O₈
- canonical SMILES
- C1C(C2C(O1)C(CO2)O[N+](=O)[O-])O[N+](=O)[O-]
- isomeric SMILES
- C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O[N+](=O)[O-])O[N+](=O)[O-]
- subject has role
- essential medicine
- World Health Organisation international non-proprietary name
- isosorbide dinitrate
- Commons category
- Isosorbide dinitrate
- defined daily dose
- 60
- significant drug interaction
- avanafil
Sources (6)
via Wikidata · CC0
Article · Deutsch
Isosorbiddinitrat (ISDN) ist ein Arzneistoff zur Behandlung der Angina Pectoris bzw. Koronarsklerose. Es verbessert die Sauerstoffversorgung des Myokards und senkt gleichzeitig den Sauerstoffverbrauch im Myokard, indem es die sogenannte Vorlast verringert. Ähnliche Wirkung hat Isosorbidmononitrat. Isosorbiddinitrat wurde 1938 von Goldberg aus Glucitol synthetisiert. Es ist als Generikum im Handel.
Abstract from DBpedia / Wikipedia · CC BY-SA