JARID2
Sign in to saveAlso known as JMJ, jumonji and AT-rich interaction domain containing 2
Protein Jumonji is a protein that in humans is encoded by the JARID2 gene. JARID2 is a member of the alpha-ketoglutarate-dependent hydroxylase superfamily.
Gene data
JARID2- Name
- jumonji and AT-rich interaction domain containing 2
- Type
- protein-coding
- Position
- 15,244,937–15,522,042 (+)
- Aliases
- DIDDF, JMJ
- Ensembl
- ENSG00000008083
- RefSeq RNA
- NM_001267040.1, NM_004973.4, XM_011514579.4, XM_017010833.3, XM_017010835.3
- RefSeq protein
- NP_001253969.1, NP_004964.2, XP_011512881.1, XP_016866322.1, XP_016866324.1
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
jumonji and AT-rich interaction domain containing 2
- Symbol
- JARID2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:15,244,937-15,522,042
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 31279
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3720
- genomic end
- 15522042
- genomic start
- 15246069
- chromosome
- human chromosome 6
- cytogenetic location
- 6p22.3
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Protein Jumonji is a protein that in humans is encoded by the JARID2 gene. JARID2 is a member of the alpha-ketoglutarate-dependent hydroxylase superfamily.
Jarid2 (jumonji, AT rich interactive domain 2) is a protein coding gene that functions as a putative transcription factor. Distinguished as a nuclear protein necessary for mouse embryogenesis, Jarid2 is a member of the jumonji family that contains a DNA binding domain known as the AT-rich interaction domain (ARID). In vitro studies of Jarid2 reveal that ARID along with other functional domains are involved in DNA binding, nuclear localization, transcriptional repression, and recruitment of Polycomb-repressive complex 2 (PRC2). Intracellular mechanisms underlying these interactions remain largely unknown.
Excerpted from Wikipedia’s “JARID2” article, available under the CC BY-SA 4.0 licence.