KAT6A
Sign in to saveAlso known as MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220, MRD32, MYST-3, lysine acetyltransferase 6A
K(lysine) acetyltransferase 6A (KAT6A), is an enzyme that, in humans, is encoded by the KAT6A gene. This gene is located on human chromosome 8, band 8p11.21.
Gene data
KAT6A- Name
- lysine acetyltransferase 6A
- Type
- protein-coding
- Aliases
- ARTHS, MOZ, MRD32, MYST-3, MYST3, RUNXBP2, ZC2HC6A, ZNF220
This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].
via MyGene.info
Wikidata facts
- Image
- Protein MYST3 PDB 1m36.png
Show 5 more facts
- HomoloGene ID
- 4924
- exact match
- identifiers.org/ncbigene/7994
- genomic end
- 42051994
- genomic start
- 41786997
- cytogenetic location
- 8p11.21
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Protein function
- Arboleda-Tham syndrome
- References
- Further reading
K(lysine) acetyltransferase 6A (KAT6A), is an enzyme that, in humans, is encoded by the KAT6A gene. This gene is located on human chromosome 8, band 8p11.21.
== Protein function ==