KCNIP4
Sign in to saveAlso known as CALP, KCHIP4, potassium voltage-gated channel interacting protein 4
Kv channel-interacting protein 4 is a protein that in humans is encoded by the KCNIP4 gene.
Gene data
KCNIP4- Name
- potassium voltage-gated channel interacting protein 4
- Type
- protein-coding
- Position
- 20,727,542–21,948,772 (−)
- Aliases
- CALP, KCHIP4
- Ensembl
- ENSG00000281758
- RefSeq RNA
- NM_001035003.2, NM_001035004.2, NM_001363504.2, NM_025221.6, NM_147181.4
- RefSeq protein
- NP_001030175.1, NP_001030176.1, NP_001350433.1, NP_079497.2, NP_671710.1
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
potassium voltage-gated channel interacting protein 4
- Symbol
- KCNIP4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:20,727,542-21,948,772
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 23528
- exact match
- identifiers.org/ncbigene/80333
- genetic association
- obesity
- found in taxon
- Homo sapiens
- chromosome
- human chromosome 4
- genomic start
- 20728606
- genomic end
- 21948772
- cytogenetic location
- 4p15.31-p15.2
- expressed in
- ventral tegmental area
via Wikidata · CC0
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Encyclopedic overview
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
Kv channel-interacting protein 4 is a protein that in humans is encoded by the KCNIP4 gene.
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Excerpted from Wikipedia’s “KCNIP4” article, available under the CC BY-SA 4.0 licence.