CLCN3

Name

Cl-/H+ antiporter 3

Type

protein-coding

Aliases

CLC3, ClC-3, NEDHYBA, NEDSBA

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].

via MyGene.info

Gene · Ensembl

chloride voltage-gated channel 3

Symbol

CLCN3

Biotype

Protein coding

Organism

Homo sapiens

Location

4:169,612,438-169,723,673

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

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