KRAS
Sign in to saveAlso known as C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1
KRAS (Kirsten rat sarcoma virus oncogene homologue) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate). It is called KRAS because it was first identified as a viral oncogene in the Kirsten RAt Sarcoma virus (current viral nomenclature: Kirsten murine sarcoma virus, Gammaretrovirus Kimursar). The oncogene identified was derived from a cellular ge
Gene data
KRAS- Name
- KRas proto-oncogene, GTPase
- Type
- protein-coding
- Position
- 25,205,246–25,326,473 (−)
- Aliases
- 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, K-Ras 2, KI-RAS
- Ensembl
- ENSG00000133703
- RefSeq RNA
- NM_001369786.1, NM_001369787.1, NM_004985.5, NM_033360.4, XM_047428826.1
- RefSeq protein
- NP_001356715.1, NP_001356716.1, NP_004976.2, NP_203524.1, XP_047284782.1
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
KRAS proto-oncogene, GTPase
- Symbol
- KRAS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:25,205,246-25,326,473
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- KRAS protein 3GFT.png
Show 9 more facts
- HomoloGene ID
- 37990
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3845
- genomic end
- 25403870
- genetic association
- non-small-cell lung carcinoma
- genomic start
- 25205246
- chromosome
- human chromosome 12
- cytogenetic location
- 12p12.1
- Commons category
- KRAS
Sources (7)
via Wikidata · CC0