Structure via PubChem · Public domain (PubChem)
latanoprost
Sign in to saveAlso known as PHXA-41, XA-41, Xalatan®, propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate, PhXA 41, Xalatan, isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate, Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate
Latanoprost, sold under the brand name Xalatan among others, is a medication used to treat increased pressure inside the eye (intraocular pressure). This includes ocular hypertension and open-angle glaucoma. Latanaprost is applied as eye drops to the eyes. Onset of effects is usually within four hours, and they last for up to a day.
Key facts
- Drug.C
- 26
- Drug.H
- 40
- Drug.O
- 5
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 462089312
- Drug.image
- Latanoprost.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Latanoprost-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Xalatan, others
- Drug.MedlinePlus
- a697003
- Drug.DailyMedID
- Latanoprost
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- Topical eye drop
- Drug.ATC_prefix
- S01
- Drug.ATC_suffix
- EE01
- Drug.ATC_supplemental
- ,
- Drug.legal_AU
- S4
via Wikipedia infobox
Chemical data
- Formula
- C26H40O5
- Molecular weight
- 432.6 g/mol
- IUPAC name
- propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
- SMILES
- CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1CC[C@H](CCC2=CC=CC=C2)O)O)O
- InChIKey
- GGXICVAJURFBLW-CEYXHVGTSA-N
- XLogP
- 4.3
- Polar surface area
- 87 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
2,387 papers- Latanoprost and pigmentation.Japanese journal of ophthalmology · 2004
- Latanoprost versus combined timolol and dorzolamide.Survey of ophthalmology · 2002
- [Long-term use of latanoprost in the treatment of glaucoma].Vestnik oftalmologii · 2020
- Latanoprost as a new horizon in the medical management of glaucoma.Current opinion in ophthalmology · 1996
- Latanoprost for the treatment of pediatric glaucoma.Survey of ophthalmology · 2002
via PubMed
~7 min read
Encyclopedic overview
19 sectionsContents
- Medical uses
- Open-angle glaucoma
- Closed-angle glaucoma
- Adverse effects
- Pregnancy
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Chemistry
- Stability
- Society and culture
- Legal status
- Brand names
- Cosmetic use
- Research
- Hair loss
- See also
- References
Latanoprost, sold under the brand name Xalatan among others, is a medication used to treat increased pressure inside the eye (intraocular pressure). This includes ocular hypertension and open-angle glaucoma. Latanaprost is applied as eye drops to the eyes. Onset of effects is usually within four hours, and they last for up to a day.
Common side effects include blurry vision, redness of the eye, itchiness, and darkening of the iris. Latanoprost is in the prostaglandin analogue family of medications. It works by increasing the outflow of aqueous fluid from the eyes through the uveoscleral tract.
Excerpted from Wikipedia’s “latanoprost” article, available under the CC BY-SA 4.0 licence.