Structure via PubChem · Public domain (PubChem)
indoprofen
Sign in to saveAlso known as K-4277, 2-(4-(1-Carboxyethyl)phenyl)-1-isoindolinone, K 4277, alpha-(4-(1-Oxo-2-isoindolinyl)phenyl)propionic acid, 1-Oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline
Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.
Chemical data
- Formula
- C17H15NO3
- Molecular weight
- 281.3 g/mol
- IUPAC name
- 2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]propanoic acid
- SMILES
- CC(C1=CC=C(C=C1)N2CC3=CC=CC=C3C2=O)C(=O)O
- InChIKey
- RJMIEHBSYVWVIN-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 57.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1979
- Indications
- rheumatic disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 281.105
- Has use
- medication
Show 4 more facts
- chemical formula
- C₁₇H₁₅NO₃
- canonical SMILES
- CC(C1=CC=C(C=C1)N2CC3=CC=CC=C3C2=O)C(=O)O
- World Health Organisation international non-proprietary name
- indoprofen
- Commons category
- Indoprofen
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.
A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.
Excerpted from Wikipedia’s “indoprofen” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
Available in 9 languages
via Wikidata sitelinks · CC0