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GeneQ17915657· pop 5· linked from 489 articles

LPAR1

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Also known as receptor 1, lysophosphatidic acid receptor 1

Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene. LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Gene data

LPAR1
Name
lysophosphatidic acid receptor 1
Type
protein-coding
Position
110,871,773–111,038,863 (−)
Aliases
EDG2, Gpcr26, LPA1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1
Ensembl
ENSG00000198121
RefSeq RNA
NM_001351397.2, NM_001351398.2, NM_001351399.2, NM_001351400.2, NM_001351401.2
RefSeq protein
NP_001338326.1, NP_001338327.1, NP_001338328.1, NP_001338329.1, NP_001338330.1

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020].

Gene Ontology

Pathways

Rap1 signaling pathway - Homo sapiens (human)Phospholipase D signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Gap junction - Homo sapiens (human)Regulation of actin cytoskeleton - Homo sapiens (human)Pathogenic Escherichia coli infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Signal TransductionSignaling by GPCR

via MyGene.info

Gene · Ensembl

lysophosphatidic acid receptor 1

Symbol
LPAR1
Biotype
Protein coding
Organism
Homo sapiens
Location
9:110,871,773-111,038,863
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~2 min read

Encyclopedic overview

8 sections
Contents
  • Function
  • Cancer
  • Evolution
  • [[Sequence homology|Paralogues]]
  • See also
  • References
  • Further reading
  • External links

Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene. LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

== Function ==

Excerpted from Wikipedia’s “LPAR1” article, available under the CC BY-SA 4.0 licence.

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