LSM4

Also known as GRP, YER112W, LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.

Gene data

LSM4

Name: LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
Type: protein-coding
Aliases: GRP, YER112W

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

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Gene · Ensembl

LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated

Symbol: LSM4
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:18,306,231-18,323,112
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 134555
exact match: identifiers.org/ncbigene/25804
genomic end: 18323112
genomic start: 18306236
cytogenetic location: 19p13.11

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U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]