MAP2K6
Sign in to saveAlso known as MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, mitogen-activated protein kinase kinase 6
gen de la especie Homo sapiens
Gene data
MAP2K6- Name
- mitogen-activated protein kinase kinase 6
- Type
- protein-coding
- Position
- 69,414,683–69,553,865 (+)
- Aliases
- CRCMSL, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
- Ensembl
- ENSG00000108984
- RefSeq RNA
- NM_001330450.2, NM_002758.4, NM_031988.1, XM_005257516.3, XM_006721975.4
- RefSeq protein
- NP_001317379.1, NP_002749.2, XP_005257573.1, XP_006722038.1, XP_011523329.1
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
mitogen-activated protein kinase kinase 6
- Symbol
- MAP2K6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:69,414,683-69,553,865
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MAP2K6 PDB 3ENM.png
Show 7 more facts
- HomoloGene ID
- 55686
- exact match
- identifiers.org/ncbigene/5608
- found in taxon
- Homo sapiens
- genomic end
- 69553865
- genomic start
- 69414697
- chromosome
- human chromosome 17
- cytogenetic location
- 17q24.3
Sources (4)
via Wikidata · CC0
Article · Español
La MAP quinasa quinasa específica dual 6 (MAP2K6) es una enzima codificada en humanos por el gen MAP2K6. Esta quinasa pertenece a la familia de las proteínas quinasas específicas duales, que actúan como MAP quinasa quinasas. Las MAP quinasas, también conocidas como quinasas reguladas por señales extracelulares, actúan como punto de integración de multitud de señales bioquímicas. MAP2K6 fosforila y activa a la MAPK p38 en respuesta a citoquinas proinflamatorias o a estrés ambiental. Como componente esencial de la ruta de transducción de señales mediada por p38, esta quinasa se encuentra implicada en multitud de procesos celulares como la parada del ciclo celular inducida por estrés, la activación de la transcripción y la apoptosis.
Abstract from DBpedia / Wikipedia · CC BY-SA