MAP3K7

Name

mitogen-activated protein kinase kinase kinase 7

Type

protein-coding

Position

90,513,472–90,587,233 (−)

Aliases

CSCF, FMD2, MEKK7, TAK1, TGF1a

Ensembl

ENSG00000135341

RefSeq RNA

NM_003188.4, NM_145331.3, NM_145332.3, NM_145333.3, XM_006715553.4

RefSeq protein

NP_003179.1, NP_663304.1, NP_663305.1, NP_663306.1, XP_006715616.1

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

mitogen-activated protein kinase kinase kinase 7

Symbol

MAP3K7

Biotype

Protein coding

Organism

Homo sapiens

Location

6:90,513,472-90,587,233

Strand

Reverse (−)

Assembly

GRCh38