MAPKAPK2
Sign in to saveAlso known as MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2, MAPK activated protein kinase 2
gen de la especie Homo sapiens
Gene data
MAPKAPK2- Name
- MAPK activated protein kinase 2
- Type
- protein-coding
- Position
- 206,684,871–206,734,284 (+)
- Aliases
- MAPKAP-K2, MK-2, MK2
- Ensembl
- ENSG00000162889
- RefSeq RNA
- NM_004759.5, NM_032960.4, XM_005273353.4, XM_017002810.2, XM_047434418.1
- RefSeq protein
- NP_004750.1, NP_116584.2, XP_005273410.1, XP_016858299.1, XP_047290374.1
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
MAPK activated protein kinase 2
- Symbol
- MAPKAPK2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:206,684,871-206,734,284
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MAPKAPK2 PDB 1kwp.png
Show 8 more facts
- HomoloGene ID
- 56412
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9261
- chromosome
- human chromosome 1
- genomic start
- 206684905
- genomic end
- 206734281
- cytogenetic location
- 1q32.1
- expressed in
- islet of Langerhans
via Wikidata · CC0
Article · Español
La proteína cinasa 2 activada por MAP cinasas (MAPKAPK2) es una enzima codificada en humanos por el gen HGNC MAPKAPK2 . Esta proteína pertenece a la familia de las serina/treonina cinasas. MAPKAPK2 es regulada por medio de una fosforilación directa llevada a cabo por la MAP cinasa p38. Esta cinasa, junto con p38, parece estar implicada en multitud de procesos celulares incluyendo repuestas a estrés y a inflamación, exportación nuclear, regulación de la expresión génica y proliferación celular. La proteína de choque térmico ha demostrado ser uno de los sustratos de MAPKAPK2 en ensayos in vivo. Se han descrito dos variantes transcripcionales del gen que codifica esta cinasa, las cuales codifican dos isoformas de la enzima.
Abstract from DBpedia / Wikipedia · CC BY-SA