Structure via PubChem · Public domain (PubChem)
mephentermine
Sign in to saveAlso known as mephentermine sodium, mephentermine sulfate, Wyamine Sulfate®
Mephentermine, sold under the brand name Wyamine among others, is a sympathomimetic medication which was previously used in the treatment of low blood pressure but is mostly no longer marketed. It is used by injection into a vein or muscle, by inhalation, and by mouth.
Chemical data
- Formula
- C11H17N
- Molecular weight
- 163.26 g/mol
- IUPAC name
- N,2-dimethyl-1-phenylpropan-2-amine
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1951
- Admin. routes
- parenteral
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
292 papers- Non-medical Mephentermine Use: A Systematic Review of Literature.Journal of addiction medicine · 2025
- Mephentermine abuse - A case report.Indian journal of psychiatry · 2021
- Herculean mistake: mephentermine associated cardiomyopathy.The Physician and sportsmedicine · 2021
- Mephentermine dependence in a young Indian adult without psychosis.BMJ case reports · 2020
- Mephentermine Misuse: An Impending Crisis among Sportspersons.Journal of psychoactive drugs · 2022
via PubMed
~8 min read
Encyclopedic overview
19 sectionsContents
- Medical uses
- Available forms
- Contraindications
- Side effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Synthesis
- History
- Society and culture
- Names
- Availability
- Recreational use
- Exercise and sports
- Research
- Veterinary use
- References
Mephentermine, sold under the brand name Wyamine among others, is a sympathomimetic medication which was previously used in the treatment of low blood pressure but is mostly no longer marketed. It is used by injection into a vein or muscle, by inhalation, and by mouth.
Side effects of mephentermine include dry mouth, sedation, reflex bradycardia, arrhythmias, and hypertension. Mephentermine induces the release of norepinephrine and dopamine and is described as an indirectly acting sympathomimetic and psychostimulant. Its sympathomimetic effects are mediated by indirect activation of α- and β-adrenergic receptors. Chemically, it is a substituted phenethylamine and amphetamine and is closely related to phentermine and methamphetamine.
Excerpted from Wikipedia’s “mephentermine” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0