MEROPS
Sign in to saveMEROPS is an online database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors. The classification scheme for peptidases was published by Rawlings & Barrett in 1993, and that for protein inhibitors by Rawlings et al. in 2004. The most recent version, MEROPS 12.5, was released in September 2023.
Key facts
- Biodatabase.title
- MEROPS
- Biodatabase.description
- MEROPS: the database of proteolytic enzymes, their substrates and inhibitors.
- Biodatabase.center
- The Wellcome Trust Sanger Institute
- Biodatabase.author
- Neil D Rawlings
- Biodatabase.citation
- Rawlings & al. (2012)
- Biodatabase.released
- 2010
- Biodatabase.url
- https://www.ebi.ac.uk/merops/
via Wikipedia infobox
~4 min read
Encyclopedic overview
8 sectionsContents
- Overview
- Classification
- Family
- Clan
- Identifier
- See also
- References
- External links
MEROPS is an online database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors. The classification scheme for peptidases was published by Rawlings & Barrett in 1993, and that for protein inhibitors by Rawlings et al. in 2004. The most recent version, MEROPS 12.5, was released in September 2023.
==Overview== The classification is based on similarities at the tertiary and primary structural levels. Comparisons are restricted to that part of the sequence directly involved in the reaction, which in the case of a peptidase must include the active site, and for a protein inhibitor the reactive site. The classification is hierarchical: sequences are assembled into families, and families are assembled into clans. Each peptidase, family, and clan has a unique identifier.
Excerpted from Wikipedia’s “MEROPS” article, available under the CC BY-SA 4.0 licence.
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