Structure via PubChem · Public domain (PubChem)
met-enkephalin
Sign in to saveAlso known as POMC(237-241), L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-methionine, YGGFM
Met-enkephalin, also known as metenkefalin (INN), sometimes referred to as opioid growth factor (OGF), is a naturally occurring, endogenous opioid peptide that has opioid effects of a relatively short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids.
Chemical data
- Formula
- C27H35N5O7S
- Molecular weight
- 573.7 g/mol
- IUPAC name
- (2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
via PubChem
Drug data · ChEMBL
- Molecule type
- Protein
via ChEMBL · EBI
Research
6,988 papers- Endocrine control of hypothalamic and pituitary met-enkephalin and beta-endorphin contents.Neuroendocrinology · 1991
- Immunofluorescence with Met-enkephalin and Leu-enkephalin antibodies in the guinea pig cochlea.Hearing research · 1984
- [Methionine-enkephalin (Met-Enk) and leucine-enkephalin (Leu-Enk)].Nihon rinsho. Japanese journal of clinical medicine · 2005
- Immunocytochemical distribution of Met-enkephalin-Arg6-Gly7-Leu8 (Met-8) in the auditory system of the rat.Hearing research · 2004
- Met-enkephalin immunoreactivity in blood platelets.Life sciences · 1982
via PubMed
Wikidata facts
- Subclass of
- enkephalin
- Part of
- proopiomelanocortin
- Mass
- 573.22571946
Show 6 more facts
- chemical formula
- C₂₇H₃₅N₅O₇S
- isomeric SMILES
- CSCC[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N
- found in taxon
- Mytilus edulis
- Commons category
- Met-enkephalin
- canonical SMILES
- CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)O
Sources (3)
via Wikidata · CC0
~4 min read
Encyclopedic overview
10 sectionsContents
- History
- Chemistry
- Biochemistry
- Distribution
- Biosynthesis
- Clearance
- Biological activity
- Pharmacokinetics
- See also
- References
Met-enkephalin, also known as metenkefalin (INN), sometimes referred to as opioid growth factor (OGF), is a naturally occurring, endogenous opioid peptide that has opioid effects of a relatively short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids.
== History == Met-enkephalin was discovered and characterized by John Hughes, Hans Kosterlitz, et al. in 1975 after a search for endogenous ligands of the opioid receptors.
Excerpted from Wikipedia’s “met-enkephalin” article, available under the CC BY-SA 4.0 licence.