met-enkephalin
Sign in to saveMet-enkephalin, also known as metenkefalin (INN), sometimes referred to as opioid growth factor (OGF), is a naturally occurring, endogenous opioid peptide that has opioid effects of a relatively short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids.
Chemical data
- Formula
- C27H35N5O7S
- Molecular weight
- 573.7 g/mol
- IUPAC name
- (2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
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Research
6,988 papers- Endocrine control of hypothalamic and pituitary met-enkephalin and beta-endorphin contents.Neuroendocrinology · 1991
- Immunofluorescence with Met-enkephalin and Leu-enkephalin antibodies in the guinea pig cochlea.Hearing research · 1984
- [Methionine-enkephalin (Met-Enk) and leucine-enkephalin (Leu-Enk)].Nihon rinsho. Japanese journal of clinical medicine · 2005
- Immunocytochemical distribution of Met-enkephalin-Arg6-Gly7-Leu8 (Met-8) in the auditory system of the rat.Hearing research · 2004
- Met-enkephalin immunoreactivity in blood platelets.
Article
10 sectionsContents
- History
- Chemistry
- Biochemistry
- Distribution
- Biosynthesis
- Clearance
- Biological activity
- Pharmacokinetics
- See also
- References
Met-enkephalin, also known as metenkefalin (INN), sometimes referred to as opioid growth factor (OGF), is a naturally occurring, endogenous opioid peptide that has opioid effects of a relatively short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids.
== History == Met-enkephalin was discovered and characterized by John Hughes, Hans Kosterlitz, et al. in 1975 after a search for endogenous ligands of the opioid receptors.